Archives of Microbiology & Immunology


ISSN: 2572-9365

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Masashi Emoto

Professor of Laboratory of Immunology
Department of Laboratory Sciences
Gunma University Graduate School of Health Sciences
Gunma, Japan

Case ReportOpen Access

Ileum Perforation With Aspergillosis and Subsequent Cytomegalovirus Ileitis Bleeding in A Patient Recovery From Dengue Fever

Wen-Ching Wang1, Wen-Liang Yu2*
1Departments of Surgery, Chi Mei Medical Center, Tainan City, Taiwan
2Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan City, Taiwan

*Corresponding Author: Wen-Liang Yu, Department of Intensive Care Medicine, Chi Mei Medical Center, 901 Chung Hwa Rd., 710 Tainan City, Taiwan, Tel: +886-6-2812811;

Received: 30 August 2017; Accepted: 13 September 2017; Published: 25 September 2017


Dengue Fever; Cytomegalovirus; Aspergillosis

Untitled Document

1. Case Presentation
Recovery from severe dengue fever may not be the end of the story for some people, especially in those with chronic kidney disease, as they stand the risk of contracting Aspergillus diseases in the next stage of the illness [1, 2]. As we know, however, case of post-dengue Aspergillus ileitis with perforation and subsequent Cytomegalovirus (CMV) enteritis was not reported.

A 67 year-old woman of chronic kidney disease had fever 5 days ago. Then, she felt worsening general weakness. Besides, vomiting, abdominal discomfort and diarrhea were also noted. There was no skin rash, dyspnea, nor tarry stool. Laboratory data showed a white blood cell count of 5,150/?L; hematocrit, 47.7 %; platelet count, 10,000/?L; K, 6.39 mmol/L; blood urine nitrogen, 84 mg/dL; creatinine, 11.27 mg/dL; aspartate aminotransferase, 211 U/L; alanine aminotransferase, 172 U/L; C-reactive protein, 11.0 mg/L; and albumin, 3.6%. Tests for dengue virus immunoglobulin (Ig) IgM, IgG and nonstructural protein 1 (NS1) antigen (Ag) were all positive. The patient recovered well after intensive fluid monitoring and therapy. The platelet count rose to 110,000/?L. At 2 weeks after admission, she got a recurrent fever, diffuse abdominal pain especially at right lower quadrant, and currant jelly stool was noticed. Abdominal computed tomography scan showed ischemic bowel with intra-abdominal abscess (Figure 1A). Laparotomy surgery confirmed perforation of terminal ileum (Figure 1B). Resection of ischemic ileum and right hemicolectomy were conducted. Biopsies of the ileum showed transmural necrosis admixed with some fungal hyphae and spores. Meanwhile, the blood Aspergillus galactomannan Ag index was 0.66 (normal, < 0.5). The CMV staining was negative. Two weeks later, massive tarry stool occurred, and colonoscopy found bleeding at the anastomosis site. CMV antigenemia was 51 positive cells per 200,000 macrophages. During the following 6 weeks, the patient experienced additional 6 times of surgical intervention for partial colectomy, end-ileostomy, peritoneal toilet, loop ileostomy, and segmental resection of ileum due to recurrent stool leakage, abscess formation and small bowel bleeding. Despite antimicrobial therapy, the patient died in severe sepsis after 79 days of hospital stay. The final resected ileum biopsy confirmed CMV ileitis with perforation. The anti-CMV therapy was not given in time.


Figure 1: The computed tomography scan of the abdomen showing ischemic bowel with intra-abdominal abscess at right lower quadrant (A) and laparotomy surgery confirming perforation of terminal ileum (B)

2. Conclusion
In conclusion, gastrointestinal aspergillosis is rare and is most often discovered in immunocompromised patients. Small intestine, colon and stomach are the most common sites of involvement [3]. Cytomegalovirus ileitis can cause massive gastrointestinal bleeding in a patient following intra-abdominal surgery [4], similar to our case following operation for terminal ileum perforation. The currently reported case highlights ileitis with aspergillosis and subsequent CMV infection in a patient at the recovery stage of severe dengue fever. The Aspergillus enteritis might be attributed to dengue-related immune deficiency [5]. However, as we know, both CMV and Aspergillus infections in the context of dengue fever were not reported in the literature. Physicians should be alert to potential ileitis caused by aspergillosis and CMV infection in a patient at the post-dengue status.

None declared

Conflict of interests
The author declares no conflict of interest and no financial support regarding this work. The case study in this work was approved by the Institutional Review Board (IRB) of Chi Mei Medical Center (IRB no. 10503-005).


  1. Larbcharoensub N, Aroonroch R, Kanoksil W, Leopairut J, Nitiyanant P, Khositseth A, Tangnararatchakit K, Chuansumrit A, Yoksan S. Infection-associated hemophagocytic syndrome among patients with dengue shock syndrome and invasive aspergillosis: a case series and review of the literature. Southeast Asian J Trop Med Public Health 42 (2011): 1106-1112.
  2. Nasa P, Yadav R, Nagrani SK, Raina S, Gupta A, Jain S. Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever. Indian J Crit Care Med 18 (2014): 323?325.
  3. Bizet J, Cooper CJ, Zuckerman MJ, Torabi A, Mendoza-Ladd A. A bleeding colonic ulcer from invasive Aspergillus infection in an immunocompromised patient: a case report. J Med Case Rep 8 (2014): 407. doi: 10.1186/1752-1947-8-407.
  4. Varma V, Perera MT, Olliff S, Taniere P, Isaac J, Mirza DF. Cytomegalovirus ileitis causing massive gastrointestinal haemorrhage in a patient following hepatic resection. Trop Gastroenterol 32 (2011): 145-147.
  5. Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, et al. Impaired T cell proliferation in acute dengue infection. J Immunol 162 (1999): 5609?5615.


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